The Role of MMP-9 in Regulating Degradation of the Splenic Microvascular Basement Membrane Induced by High Altitude Hypoxia

To investigate changes of MMP-9 in the rat spleen and hypoxia-induced microvascular basement membrane under high altitude hypoxia. Thirty male specific pathogen-free Sprague Dawley rats were randomly divided into control hypoxia groups, with 15 each group. The group placed Dingxi City, Gansu Province (2080 m above sea level) for 30 days. Rats raised a hypoxic environment Maduo County, Qinghai (4300 level), days to establish model. Routine blood tests, mRNA, protein, detected. (1) Compared group, red cell count, hemoglobin, hematocrit levels all increased; thus, model was successfully established. (2) expression mRNA protein significantly higher difference statistically significant (P <0.05). (3) vessel degraded. Under natural low air pressure conditions, tissue increases participates degradation membrane.